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Kính thưa quý độc giả,
Chúng tôi nhận được email của BS Nguyễn Thượng Vũ giới thiệu một công trình nghiên cứu đăng trên website Medscape.com nói về sự liên quan của sinh tố D và nguy cơ nhiễm Covid-19. Do đây là một khía cạnh mới trong việc phòng tránh Covid-19 khá quan trọng nên chúng tôi xin được nêu lên trên Diễn Đàn này. Nguyên văn email của BS Nguyễn Thượng Vũ như sau:
Thưa các anh chị,
Tuần qua, website của JAMA online (Journal of The American Medical Association) có đăng 1 công trình khảo cứu trên 489 người tại Chicago, xem các người thiếu chất Vitamine D trong người , có dễ bị mắc bệnh với Virus Covid19 hay không?
Kết quả là các người thiếu Vitamine D trong người bị Covid19 gần gấp đôi X2 các người uống Vitamine D đầy đủ hàng ngày. (21.6% versus 12.2%)
Tôi có copy& paste vài đoạn quan trong trong bài báo Medscape viết cách đây 2 ngày.
Các anh chị có thể đọc toàn bài báo khi click trên link phía dưới.
Xin lưu ý : Công trình nghiên cứu này viết tới liên hệ giữa sự đầy đủ Vitamine D trong người và sự ít bị lây bệnh Covid19 mà thôi ( association, correlation but not causation)
Bài viết này có thể quen thuộc với các bác sĩ y khoa, tuy nhiên với các bạn hữu ngoài giới Y Nha Dược có thể không biết.
Tôi có uống Vitamine D3 nhiều năm nay để chống đau lưng và để bổ xương, tuy nhiên tin tức về Covid19 thì người ta mới viết vào khoảng 2-3 tháng nay mà thôi.
Nếu không có toa/ prescription thì tôi nghĩ mua Vitamine D3 tại Costco dễ dàng và rẻ tiền nhất. Các người ít ra nắng thì dễ bị thiếu Vitamine D nhất.
Rất thân mến.
Nguyen Thuong Vu
https://www.medscape.com/viewarticle/936928?src=mkm_covid_update_200906_mscpedit_&uac=293632SY&impID=2550189&faf=1
Vitamin D Deficiency May Boost COVID-19 Risk
People who are deficient in vitamin D may be at higher risk of contracting the novel coronavirus than those with sufficient levels, according to the results of a new retrospective study from Illinois.
Individuals with untreated vitamin D deficiency were nearly twice as likely to test positive for COVID-19 relative to their peers with adequate vitamin D levels.
"These findings appear to support a role of vitamin D status in COVID-19 risk," the authors say in the study, published online September 3 in JAMA Network Open.
"Vitamin D is important to the function of the immune system and vitamin D supplements have previously been shown to lower the risk of viral respiratory tract infections. Our statistical analysis suggests this may be true for the COVID-19 infection," lead author David Meltzer, MD, PhD, chief of hospital medicine at University of Chicago Medicine, Illinois, said in a news release from his institution.
Important for Immune Function
Meltzer and colleagues studied 489 University of Chicago Medicine patients (mean age 49 years, 75% women) whose vitamin D levels were determined in the 2 months before being tested for COVID-19.
Vitamin D deficiency was defined as < 20 ng/mL 25-hydroxycholecalciferol or < 18 pg/mL 1,25-dihydroxycholecalciferol.
Vitamin D status was categorized as likely deficient for 124 participants (25%), likely sufficient for 287 (59%), and uncertain for 78 (16%).
A total of 71 participants (15%) tested positive for COVID-19.
In a multivariate analysis, a positive COVID-19 test was significantly more likely in those with likely vitamin D deficiency than in those with likely sufficient vitamin D levels at the time of COVID-19 testing (relative risk [RR], 1.77; 95% CI, 1.12 - 2.81; P = .02).
The estimated mean rate of COVID-19 in the deficient group was 21.6% compared with 12.2% in the sufficient group.
Testing positive for COVID-19 was also associated with increasing age up to age 50 years (RR, 1.06; P = .02) and race other than White (RR, 2.54; P = .009)
Protective Effect of Treatment?
The findings also raise the possibility that treatment for vitamin D deficiency may lower the risk of COVID-19, the researchers say.
Patients with deficient vitamin D levels who had their vitamin D treatment increased did not appear to have increased risk for COVID-19.
This suggests a "protective effect of treatment, but the confidence intervals on estimated rates for these groups are too wide to exclude the possibility of no treatment effect," Meltzer and colleagues note.
"If vitamin D does reduce COVID-19 incidence, it is tempting to consider whether it might reduce COVID-19 transmission," they hypothesize.
Because vitamin D strengthens innate immunity it could be expected to decrease COVID-19 infection and transmission. Vitamin D also affects zinc metabolism, which decreases replication of coronaviruses.
As previously reported by Medscape Medical News, a recent study from Israel suggested low plasma vitamin D levels are an independent risk factor for COVID-19 infection and hospitalization.
In that study, participants positive for COVID-19 were 50% more likely to have low vs normal vitamin D levels in a multivariate analysis that controlled for other confounders.
Half of Americans are deficient in Vitamin D, with much higher rates seen in African Americans, Hispanics, and individuals living in areas like Chicago where it is difficult to get enough sun exposure in winter.
"Understanding whether treating Vitamin D deficiency changes COVID-19 risk could be of great importance locally, nationally, and globally," Meltzer said. "Vitamin D is inexpensive, generally very safe to take, and can be widely scaled."
Meltzer and colleagues say randomized clinical trials are now needed to see whether broad population interventions and interventions among groups at increased risk of vitamin D deficiency and COVID-19 could reduce COVID-19 cases.
The study was supported by the Learning Health Care System Core of the University of Chicago/Rush University Institute for Translational Medicine (ITM) Clinical and Translational Science Award and the African American Cardiovascular Pharmacogenetics Consortium. The authors have declared no relevant conflicts of interest.
JAMA Netw Open. Published September 3, 2020.
Full text
Kính thưa quý độc giả,
Chúng tôi nhận được email của BS Nguyễn Thượng Vũ giới thiệu một công trình nghiên cứu đăng trên website Medscape.com nói về sự liên quan của sinh tố D và nguy cơ nhiễm Covid-19. Do đây là một khía cạnh mới trong việc phòng tránh Covid-19 khá quan trọng nên chúng tôi xin được nêu lên trên Diễn Đàn này. Nguyên văn email của BS Nguyễn Thượng Vũ như sau:
Thưa các anh chị,
Tuần qua, website của JAMA online (Journal of The American Medical Association) có đăng 1 công trình khảo cứu trên 489 người tại Chicago, xem các người thiếu chất Vitamine D trong người , có dễ bị mắc bệnh với Virus Covid19 hay không?
Kết quả là các người thiếu Vitamine D trong người bị Covid19 gần gấp đôi X2 các người uống Vitamine D đầy đủ hàng ngày. (21.6% versus 12.2%)
Tôi có copy& paste vài đoạn quan trong trong bài báo Medscape viết cách đây 2 ngày.
Các anh chị có thể đọc toàn bài báo khi click trên link phía dưới.
Xin lưu ý : Công trình nghiên cứu này viết tới liên hệ giữa sự đầy đủ Vitamine D trong người và sự ít bị lây bệnh Covid19 mà thôi ( association, correlation but not causation)
Bài viết này có thể quen thuộc với các bác sĩ y khoa, tuy nhiên với các bạn hữu ngoài giới Y Nha Dược có thể không biết.
Tôi có uống Vitamine D3 nhiều năm nay để chống đau lưng và để bổ xương, tuy nhiên tin tức về Covid19 thì người ta mới viết vào khoảng 2-3 tháng nay mà thôi.
Nếu không có toa/ prescription thì tôi nghĩ mua Vitamine D3 tại Costco dễ dàng và rẻ tiền nhất. Các người ít ra nắng thì dễ bị thiếu Vitamine D nhất.
Rất thân mến.
Nguyen Thuong Vu
https://www.medscape.com/viewarticle/936928?src=mkm_covid_update_200906_mscpedit_&uac=293632SY&impID=2550189&faf=1
Vitamin D Deficiency May Boost COVID-19 Risk
People who are deficient in vitamin D may be at higher risk of contracting the novel coronavirus than those with sufficient levels, according to the results of a new retrospective study from Illinois.
Individuals with untreated vitamin D deficiency were nearly twice as likely to test positive for COVID-19 relative to their peers with adequate vitamin D levels.
"These findings appear to support a role of vitamin D status in COVID-19 risk," the authors say in the study, published online September 3 in JAMA Network Open.
"Vitamin D is important to the function of the immune system and vitamin D supplements have previously been shown to lower the risk of viral respiratory tract infections. Our statistical analysis suggests this may be true for the COVID-19 infection," lead author David Meltzer, MD, PhD, chief of hospital medicine at University of Chicago Medicine, Illinois, said in a news release from his institution.
Important for Immune Function
Meltzer and colleagues studied 489 University of Chicago Medicine patients (mean age 49 years, 75% women) whose vitamin D levels were determined in the 2 months before being tested for COVID-19.
Vitamin D deficiency was defined as < 20 ng/mL 25-hydroxycholecalciferol or < 18 pg/mL 1,25-dihydroxycholecalciferol.
Vitamin D status was categorized as likely deficient for 124 participants (25%), likely sufficient for 287 (59%), and uncertain for 78 (16%).
A total of 71 participants (15%) tested positive for COVID-19.
In a multivariate analysis, a positive COVID-19 test was significantly more likely in those with likely vitamin D deficiency than in those with likely sufficient vitamin D levels at the time of COVID-19 testing (relative risk [RR], 1.77; 95% CI, 1.12 - 2.81; P = .02).
The estimated mean rate of COVID-19 in the deficient group was 21.6% compared with 12.2% in the sufficient group.
Testing positive for COVID-19 was also associated with increasing age up to age 50 years (RR, 1.06; P = .02) and race other than White (RR, 2.54; P = .009)
Protective Effect of Treatment?
The findings also raise the possibility that treatment for vitamin D deficiency may lower the risk of COVID-19, the researchers say.
Patients with deficient vitamin D levels who had their vitamin D treatment increased did not appear to have increased risk for COVID-19.
This suggests a "protective effect of treatment, but the confidence intervals on estimated rates for these groups are too wide to exclude the possibility of no treatment effect," Meltzer and colleagues note.
"If vitamin D does reduce COVID-19 incidence, it is tempting to consider whether it might reduce COVID-19 transmission," they hypothesize.
Because vitamin D strengthens innate immunity it could be expected to decrease COVID-19 infection and transmission. Vitamin D also affects zinc metabolism, which decreases replication of coronaviruses.
As previously reported by Medscape Medical News, a recent study from Israel suggested low plasma vitamin D levels are an independent risk factor for COVID-19 infection and hospitalization.
In that study, participants positive for COVID-19 were 50% more likely to have low vs normal vitamin D levels in a multivariate analysis that controlled for other confounders.
Half of Americans are deficient in Vitamin D, with much higher rates seen in African Americans, Hispanics, and individuals living in areas like Chicago where it is difficult to get enough sun exposure in winter.
"Understanding whether treating Vitamin D deficiency changes COVID-19 risk could be of great importance locally, nationally, and globally," Meltzer said. "Vitamin D is inexpensive, generally very safe to take, and can be widely scaled."
Meltzer and colleagues say randomized clinical trials are now needed to see whether broad population interventions and interventions among groups at increased risk of vitamin D deficiency and COVID-19 could reduce COVID-19 cases.
The study was supported by the Learning Health Care System Core of the University of Chicago/Rush University Institute for Translational Medicine (ITM) Clinical and Translational Science Award and the African American Cardiovascular Pharmacogenetics Consortium. The authors have declared no relevant conflicts of interest.
JAMA Netw Open. Published September 3, 2020.
Full text
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